Cool Idea on Wired.com’s Blog - Enter and Vote your fav tech April Fools Prank (Digg Style)
Swap Their Mouse Buttons by Wired News
Set left-click as right-click and vice versa. This one is so simple, it’s best reserved for the truly helpless. To make it a little more annoying, slow down the double-click speed while you’re at it.
Set. I'll do that to my brother. Watch out for the update on how it went. :D